Over the past decade, the technologies and analysis to study cells in tissue context have evolved significantly. They now allow to comprehensively understand molecular mechanisms in health and disease, providing information about the effect of environmental and microenvironmental cues in the tissue. This includes effects of mechanical stimuli on cells. In this session, Adrien Hallou will give us an overview about the novel field of mechano-transcriptomics, which investigates how mechanical cues shape transcriptional profiles within the tissue context.